Tell Vitamin B12 Deficiency
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Moved from Talk:Cobalamin
:
In accordance with Wikipedia:WikiProject_Drugs naming policy, I propose we move this page to the INN cyanocobalamin. If you have any concern with this proposal, please discuss it on this page. Matt 00:06, 22 Dec 2004 (UTC)
Broken Links
All the External Links except Vitamin B-12 deficiency article in American Family Physician journal, and MeSH Cyanocobalamin are broken.
http://ods.od.nih.gov/factsheets/vitaminb12.asp#h2 NIH Fact sheet link also broken.
The page should be renamed to B-12
The present name "cyanocobalamin" is misleading, as this substance is not equivalent with vitamin B12 and does not occur in nature. It is not well assimilated by the body. Moreover it is transformed to harmful cyanides when metabolized.
Cyanocobalamin has been the most used drug for supplementing B12, but this is only because it has been the most profitable substance to produce. By using the name Cyanocobalamin for B12 commercial interests are supported at the expense of public health, because Cyanocobalamin is not a good supplement for reasons as follows.
There exists increasing evidence indicating that the use of cyanocobalamine for neurological disorders including Alzheimers diseas is inadequate, because it is not well taken upp by the nervous system. Some researchers have even suggested that a factor in at least in some cases of Alzheimers, is a weak uptake of B12 into the brain circulation. Tragically, some studies using cyanocobalamin for Alzheimer have concluded that B12 is not very effective treatment for Alzheimer, while in reality the reason may have been that the preparation was not taken up by the brain. On the other hand, studies using methylcobalamin for Alzheimer have reported good results. Methylcobalamin is the natural form that is especially useful for the brain.
Actually, the medical use of cyanocobalamin has been questioned by some scientists. S.I. Terry pointed out in the Lancet that an incalculable number of people with neurological disorders due to B12-deficency are put at risk because of the inability of cyanocobalamin to correct the B12 deficiency in the nervous system. (Terry, S.I. et al. "Survival of Cyanocobalmin." The Lancet, October 14, 1978, pg. 848.)
Dr Linnel pointed out that cyanocobalamin has no known biochemical function and needs to be transformed in the body to physiologic cobalamins before it can be used. He concluded that there is no place for the therapeutic usage of cyanocobalamin (Linnell, J.C. et al. "Therapeutic Misuse of Cyanocobalamin". Lancet, November 11, 1978; pg 1053-1054.)
As deficiency in the nervous system is an especially serious complication of vitamin B12 deficiency, a name should not be used that makes people wrongly believe that cyanocobalamin is equivalent with vitamin B12 and therefore an adequate treatment for such serious disorders.
Methylcobalamin is actually the predominant form of B12 in the body as 90% of the active form of B12 in the blood is this molecule. But in the liver, kidney, brain and erythrocyters, adenosylcobalamin (also called dibencozide) is predominant.
So as there are different forms of B12 in the body, it would be sensible and most adequate to use the simple common denominator "vitamin B12".
Finally, the motivation for renaming from B12 to cyanocobalamin was that this was in accordance with Wikipedia:WikiProject_Drugs naming policy. However, B12 is not a drug (but cyanocobalamin is), it is a common denominator for a group of physiological molecules of vital importance for the normal functioning of the body.
CONCLUSION : There are strong reasons why the cyanocobalamin page should be renamed back to its original name "B12".
--Võitkutõde 06:10, 19 June 2007 (UTC) M.D.
I second this. I think that this page should either be about B12 in general or cyanocobalamin specifically. Cyanocobalamin is the most ineffective form of B12 so it should not be equated with the vitamin.24.83.178.11 07:29, 2 November 2007 (UTC)BeeCier
Thank you for moving this page. Having "Vitamin B-12" redirect to "Cyanocobalamin" was pretty misinformative. Sowelilitokiemu (talk) 05:59, 10 March 2008 (UTC)
Other species' needs for vitamin B-12 besides human beings
What other species need vitamin B-12 from outside sources (their diets)? This should be listed in this article. For example, it is a widely-known fact that human beings need vitamin C from their diets, and that guinea pigs need to eat it, too, but that most other animals produce their own vitamin C. It would be good to have at least a bare-bones level of this information here for vitamin B-12, instead of concentrating 98% on human beings. DAW
Some strange citations
Some of those external links are pretty bad. The Advice for vegans on B article sounds like it was written by a high school student. Also the Vitamin B information seems to be down. I'm not sure if the site is gone for good or what. I'll have to see if I can add a bit to this article. --Genericdave 22:50, 23 October 2005 (UTC)
Which bacteria?
Which bacteria produces B12? Anybody know the species?
A number of species. Often Kleibisilla(sp?) and Pseudomonas are used —Preceding unsigned comment added by 76.166.24.76 (talk) 06:08, 2 January 2009 (UTC)
no copyrighted materials
Please, don't submit copyrighted material. There was just now a lot of material added to the article, and some of it (in the Structure section) was taken more or less verbatim from ISBN 0471496405. I removed the whole edit because at least a part of it was copyrighted. --Andkaha (talk) 23:49, 16 October 2005 (UTC)
Someone should take a look at this and relate it with the b12 article:
http://www.rawbc.org/articles/B12.html
It could be explored the nutritional side of it and the vegetarian, etc., diets and relation to B-12
Why is there no information about
miso
- a paste that is well known to contain B12 and fits the vegan dietry? And if B12 is present only is non-vegan food, how comes that meat eaters also have a lack of B12? Some statements simply seem to be either contradicting each other, or to be based on still not enough researched ground. 84.145.231.254 02:43, 15 January 2006 (UTC) renu
An interesting question is, how comes that cows have a lot of B-12? Do they eat other cows, or all their life drink cow-milk?? I don't know about such ones, I must admit. Ra
heard that E.coli do produce it (by rumor of course)
From page
This was posted as a HTML comment in the article. I thought it would get more attention here.
Matt 00:12, 24 February 2006 (UTC)
I think the part refering to the Steven Segal drink should be striken. Remember 18:45, 1 March 2006 (UTC)
mcg?
Why is this article using mcg instead of µg? Should it be changed? 218.103.142.233 03:35, 19 March 2006 (UTC)
The usage on packaging for food supplements is mcg. Perhaps the public is not familiar with what µ means. in the 1960's, I learned these prefixes from ripping old radios apart and learning how capacitors' values are measured (in µfd and pfd).
Angelica sinensis
Quote: The only known vegan sources of substantial B12 ... are the Chinese herb Dang Gui (Angelica sinensis), used for centuries for treating anemia
Every so often, a new claim about vegetable sources of vitamin B12 pops up. The problem is that some plants do contain molecules structurally related to the known variants which might be new forms of vitamin B12 (AFAIK the only substances known to be fully active vitamin B12 are cyanocobalamin and methylcobalamin), but they are not known to provide full vitamin B12 activity in humans, or even known not to provide it. For example, the
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